内科学
胰岛素抵抗
内分泌学
福克斯O1
信号转导
河马信号通路
生物
纤维化
条件基因敲除
肝纤维化
肝星状细胞
激活剂(遗传学)
基因敲除
癌症研究
基因剔除小鼠
医学
胰岛素
表型
细胞生物学
基因
蛋白激酶B
受体
生物化学
作者
Yujiao Dai,Hao Peng,Zhimei Sun,Zhiyi Guo,Hong Xu,Lihui Xue,Hongyu Song,Yida Li,Shuang Li,Mingming Gao,Si Teng,Yuxin Zhang,Yajuan Qi
摘要
Yes-associated protein (YAP), as a co-activator of transcription factors, is a downstream protein in the Hippo signaling pathway with important functions in cell proliferation, apoptosis, invasion and migration. YAP also plays a key role in the development of CCl 4 -induced liver fibrosis. However, the mechanism of YAP during hepatic fibrosis progression and reversion is still unclear. Mild liver fibrosis was developed after 4 months of high-fat diet (HFD) stimulation, and we found that the YAP signaling pathway was activated. Here, we aim to reveal whether specific knockout of Yap gene in the liver can improve liver fibrosis induced by insulin resistance (IR) stimulated by HFD, and further explain its specific mechanism. We found that liver-specific Yap gene knockout improved IR-induced liver fibrosis and liver dysfunction, and this mechanism is related to the inhibition of the insulin signal pathway at the FoxO1 level. These findings provide a new insight, and Yap is expected to be a new target to reverse the early stage of liver fibrosis induced by IR.
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