医学
骨愈合
骨形成
叙述性评论
刺激
重症监护医学
生物信息学
外科
内科学
生物
作者
Giovanni Vicenti,Davide Bizzoca,Giuseppe Solarino,Francesco Moretti,Guglielmo Ottaviani,F Simone,Giacomo Zavattini,Giuseppe Maccagnano,G. Noia,Biagio Moretti
出处
期刊:Journal of Biological Regulators and Homeostatic Agents
日期:2020-09-01
卷期号:34 (5): 131-135
被引量:19
摘要
Clinical biophysics investigates the relationship between non-ionizing physical energy and the human body. This narrative review aims to summarize the current evidence on the efficacy of PEMF-therapy in the promotion of fracture healing. The effectiveness of PEMFs has been deeply investigated in preclinical in vitro ed in vivo studies and level-I clinical studies. All these studies depicted only PEMF-devices with specific physical wave features - i.e. pulse shape, frequency and amplitude- could significantly promote bone repair. Moreover, the dose-response relationship was also defined in preclinical studies, thus providing the minimum exposure time needed in PEMF-therapy. PEMFs are currently employed in the management several bone injuries, including acute fractures at non-union risk, non-unions, osteotomies, stress fractures and osteonecrosis. Moreover, several ongoing studies are investigating the effectiveness of PEMFs on emerging clinical conditions, thus the indications to PEMF-therapy could potentially raise in future years.
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