Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

生物相容性 丝素 伤口愈合 芦荟 银纳米粒子 体内 生物材料 化学 生物医学工程 磺胺嘧啶银 活力测定 材料科学 丝绸 体外 纳米技术 纳米颗粒 医学 外科 传统医学 复合材料 有机化学 生物技术 生物 生物化学
作者
Yangkun Liu,JinChuan Fan,Mingqi Lv,Kepeng She,Jiale Sun,Qingqing Lu,Changhao Han,Songtao Ding,Shuang Zhao,Guixue Wang,YuChan Zhang,Guangchao Zang
出处
期刊:Regenerative Biomaterials [University of Oxford]
卷期号:8 (6) 被引量:38
标识
DOI:10.1093/rb/rbab048
摘要

Abstract Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties and biological activity must be further improved. In this study, a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds. The composite hydrogel (Ag–AV–SF hydrogel) was prepared by introducing the silver nanoparticles (AgNPs) and aloe vera (AV) as the modifiers. In vitro study exhibited great antibacterial ability, biocompatibility and cell-proliferation and -migration-promoting capacities. It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment. The healing effect evaluation in vivo showed the healing-promoting ability of the Ag–AV–SF hydrogel was stronger than the single-modifiers groups, and the healing rate of it reached 97.02% on Day 21, higher than the commercial wound dressing, silver sulfadiazine (SS) cream on sale. Additionally, the histological and protein expression results showed that the Ag–AV–SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage, reconstructing the blood vessels networks and inhibiting the formation of scars. In summary, the Ag–AV–SF hydrogel developed in this study had good physical properties, overwhelming antibacterial properties, satisfactory biocompatibility and significantly promoting effect on cell proliferation, migration and wound healing. Overall, our results suggest that the Ag–AV–SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Jolie完成签到,获得积分10
刚刚
2秒前
2秒前
wh发布了新的文献求助10
3秒前
慕青应助zyc采纳,获得10
4秒前
5秒前
呐呐发布了新的文献求助10
5秒前
5秒前
科研通AI5应助科研通管家采纳,获得30
5秒前
小马甲应助科研通管家采纳,获得10
6秒前
李健应助科研通管家采纳,获得10
6秒前
科研通AI5应助科研通管家采纳,获得10
6秒前
彭于晏应助科研通管家采纳,获得10
6秒前
开开SWAG发布了新的文献求助10
6秒前
科目三应助科研通管家采纳,获得10
6秒前
毛豆应助科研通管家采纳,获得10
6秒前
zhou应助科研通管家采纳,获得10
6秒前
汉堡包应助科研通管家采纳,获得10
6秒前
科研通AI5应助科研通管家采纳,获得30
6秒前
6秒前
传奇3应助科研通管家采纳,获得10
6秒前
lee应助科研通管家采纳,获得10
6秒前
科研通AI5应助科研通管家采纳,获得10
6秒前
Owen应助科研通管家采纳,获得10
6秒前
6秒前
完美世界应助科研通管家采纳,获得10
6秒前
wanci应助科研通管家采纳,获得10
6秒前
科研通AI2S应助科研通管家采纳,获得10
7秒前
在水一方应助科研通管家采纳,获得10
7秒前
余生发布了新的文献求助10
7秒前
汉堡包应助科研通管家采纳,获得10
7秒前
科研通AI5应助科研通管家采纳,获得30
7秒前
于水清应助科研通管家采纳,获得10
7秒前
所所应助科研通管家采纳,获得10
7秒前
7秒前
7秒前
烟花应助如意的玉米采纳,获得10
8秒前
应万言完成签到,获得积分0
9秒前
星辰大海应助jiangqingquan采纳,获得10
10秒前
yanyanyan发布了新的文献求助10
11秒前
高分求助中
All the Birds of the World 4000
Production Logging: Theoretical and Interpretive Elements 3000
Les Mantodea de Guyane Insecta, Polyneoptera 2000
Homolytic deamination of amino-alcohols 1000
Machine Learning Methods in Geoscience 1000
Weirder than Sci-fi: Speculative Practice in Art and Finance 960
Resilience of a Nation: A History of the Military in Rwanda 888
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3728371
求助须知:如何正确求助?哪些是违规求助? 3273407
关于积分的说明 9981640
捐赠科研通 2988820
什么是DOI,文献DOI怎么找? 1639851
邀请新用户注册赠送积分活动 779001
科研通“疑难数据库(出版商)”最低求助积分说明 747863