Photocrosslinking silver nanoparticles–aloe vera–silk fibroin composite hydrogel for treatment of full-thickness cutaneous wounds

生物相容性 丝素 伤口愈合 芦荟 银纳米粒子 体内 生物材料 化学 生物医学工程 磺胺嘧啶银 活力测定 材料科学 丝绸 体外 纳米技术 纳米颗粒 医学 外科 传统医学 复合材料 有机化学 生物技术 生物 生物化学
作者
Yangkun Liu,JinChuan Fan,Mingqi Lv,Kepeng She,Jiale Sun,Qingqing Lu,Changhao Han,Songtao Ding,Shuang Zhao,Guixue Wang,YuChan Zhang,Guangchao Zang
出处
期刊:Regenerative Biomaterials [Oxford University Press]
卷期号:8 (6) 被引量:37
标识
DOI:10.1093/rb/rbab048
摘要

Abstract Damage to the skin causes physiological and functional issues. The most effective treatment approach is the use of wound dressings. Silk fibroin (SF) is a promising candidate biomaterial for regulating wound healing; however, its antibacterial properties and biological activity must be further improved. In this study, a photocrosslinking hydrogel was developed to treat full-thickness cutaneous wounds. The composite hydrogel (Ag–AV–SF hydrogel) was prepared by introducing the silver nanoparticles (AgNPs) and aloe vera (AV) as the modifiers. In vitro study exhibited great antibacterial ability, biocompatibility and cell-proliferation and -migration-promoting capacities. It also showed the pH-response releasing properties which release more AgNPs in a simulated chronic infection environment. The healing effect evaluation in vivo showed the healing-promoting ability of the Ag–AV–SF hydrogel was stronger than the single-modifiers groups, and the healing rate of it reached 97.02% on Day 21, higher than the commercial wound dressing, silver sulfadiazine (SS) cream on sale. Additionally, the histological and protein expression results showed that the Ag–AV–SF hydrogel has a greater effect on the pro-healing regenerative phenotype with M2 macrophages at the early stage, reconstructing the blood vessels networks and inhibiting the formation of scars. In summary, the Ag–AV–SF hydrogel developed in this study had good physical properties, overwhelming antibacterial properties, satisfactory biocompatibility and significantly promoting effect on cell proliferation, migration and wound healing. Overall, our results suggest that the Ag–AV–SF hydrogel we developed has great potential for improving the wound healing in clinical treatment.
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