促炎细胞因子
免疫学
炎症
疾病
自身免疫性疾病
功能(生物学)
调节性T细胞
自身免疫
生物
医学
T细胞
白细胞介素2受体
免疫系统
细胞生物学
抗体
病理
作者
Victoire Gouirand,Ireneusz Habrylo,Michael D. Rosenblum
标识
DOI:10.1016/j.jid.2021.05.010
摘要
Regulatory T cells (Tregs) play a critical role in regulating tissue inflammation. Reduced Treg numbers and/or suppressive function contribute to autoimmune disease. Tregs can adopt the transcriptional programming of T helper (Th) type-1/2/17 cells to optimally suppress these subsets. Under specific conditions, these Th-like Tregs lose suppressive capacity and release proinflammatory cytokines to promote inflammation. This Treg plasticity depends on inflammatory mediators in the local environment. In this study, we review how cytokines impact Treg function and may contribute to autoimmune disease. A comprehensive understanding of Th-like Tregs may elucidate novel and more focused therapeutic approaches.
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