Morphology-controllable amphiphilic cellulose microgels made from self-assembly of hydrophobic long-chain bromide-alkylated-cellulose/gelatin copolymer

A cellulose-based microgel is firstly synthesized via chemically coupling gelatin and cellulose, and then amphiphilic cellulose copolymers (HMGC) are prepared by alkylated cellulose-based microgel from different long-chain alkyl groups. The long-chain alkyl group is mainly bonded onto the residual hydroxyl group at C6 from the AGU of cellulose and the imino groups of gelatin, respectively. The results of self-assembly behavior of HMGC demonstrate that the critical aggregation concentrations of the microgels are in the range from 0.628 to 0.075 mg/mL, and the corresponding hydrodynamic diameters are between 104–1000 nm. Besides, the HMGC can self-assemble into microgels of various morphologies including cotton flocculence, sphere, rod-like, vesicle, flower-like cluster, snowflake-like, urchin-like, and coral shapes. These novel morphologies can be controlled by adjusting the degree of alkylation, the length of the alkyl chain, and the concentration of microgel. Furthermore, the possible formation mechanism of the multiform microgels is proposed from the chain conformation.