Based on a six-storey cross-laminated timber building equipped with a base isolation system, this article proposes predictive models for the fundamental period of vibration, a parameter that needs to be selected in early stages of a seismically isolated building's design process, in relation to economic losses, such as repair costs and repair time, and environmental losses, such as repair-related carbon footprint and embodied energy. The predictive models were calibrated using a dataset of 114 bidirectional accelerograms recorded in Chile between 1985 and 2020, with event magnitudes ranging from Mw 7 to Mw 8.8. A single functional form was selected for the four resilience parameters used, having an average coefficient of determination of R2 = 0.62. Results suggest that the selection of the fundamental period of vibration of a mid-rise seismically isolated CLT building can have a significant impact on the potential economic and environmental losses likely to occur when subjected to severe seismic events, and therefore, its selection should be based not only on technical aspects but also resilience and sustainability parameters.