癌症研究
HDAC8型
免疫检查点
生物
免疫系统
免疫疗法
乙酰化
免疫学
组蛋白脱乙酰基酶
组蛋白
生物化学
基因
作者
Weiqin Yang,Yu Feng,Jingying Zhou,Otto Ka-Wing Cheung,Jian Cao,Jing Wang,Wenshu Tang,Yalin Tu,Liangliang Xu,Feng Wu,Zhiwu Tan,Hanyong Sun,Yuan Tian,John Wong,Paul B.S. Lai,Stephen L. Chan,Anthony W.H. Chan,Patrick Tan,Zhiwei Chen,Joseph J.�Y. Sung,Kevin Y. Yip,Ka‐Fai To,Alfred S.L. Cheng
出处
期刊:Science Translational Medicine
[American Association for the Advancement of Science (AAAS)]
日期:2021-04-07
卷期号:13 (588)
被引量:92
标识
DOI:10.1126/scitranslmed.aaz6804
摘要
HDAC8 inhibition elicits durable responses to immune checkpoint blockade by improving adaptive immune responses through enhancer reprogramming.
科研通智能强力驱动
Strongly Powered by AbleSci AI