Cognition in prodromal Parkinson's disease

前驱期 认知 心理学 疾病 心理干预 帕金森病 临床心理学 精神科 医学 认知障碍 病理
作者
Inga Liepelt‐Scarfone,Anja Ophey,Elke Kalbe
出处
期刊:Progress in Brain Research 卷期号:: 93-111 被引量:12
标识
DOI:10.1016/bs.pbr.2022.01.003
摘要

One characteristic of Parkinson's disease (PD) is a prodromal phase, lasting many years during which both pre-clinical motor and non-motor symptoms occur. Around one-fifth of patients with PD manifest mild cognitive impairment at time of clinical diagnosis. Thus, important challenges are to define the time of onset of cognitive dysfunction in the prodromal phase of PD, and to define its co-occurrence with other specific characteristics. Evidence for cognitive change in prodromal PD comes from various study designs, including both longitudinal and cross-sectional approaches with different target groups. These studies support the concept that changes in global cognitive function and alterations in executive functions occur, and that these changes may be present up to 6 years before clinical PD diagnosis. Notably, this evidence led to including global cognitive impairment as an independent prodromal marker in the recently updated research criteria of the Movement Disorder Society for prodromal PD. Knowledge in this field, however, is still at its beginning, and evidence is sparse about many aspects of this topic. Further longitudinal studies including standardized assessments of global and domain-specific cognitive functions are needed to gain further knowledge about the first appearance, the course, and the interaction of cognitive deficits with other non-motor symptoms in prodromal stage PD. Treatment approaches, including non-pharmacological interventions, in individuals with prodromal PD might help to prevent or delay cognitive dysfunction in early PD.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
北媛完成签到,获得积分10
1秒前
2秒前
2秒前
阳光完成签到 ,获得积分10
2秒前
潇潇完成签到 ,获得积分10
3秒前
4秒前
4秒前
4秒前
4秒前
北媛发布了新的文献求助30
5秒前
5秒前
6秒前
共享精神应助蟹蟹采纳,获得10
7秒前
翼点发布了新的文献求助10
8秒前
10秒前
keal完成签到,获得积分10
11秒前
沉静紫安发布了新的文献求助10
11秒前
郭德好发布了新的文献求助20
12秒前
生动惜灵应助弄巷采纳,获得10
13秒前
专注的玉米完成签到,获得积分10
14秒前
义气的惜海完成签到,获得积分10
15秒前
SciGPT应助水星记采纳,获得10
16秒前
17秒前
17秒前
17秒前
珍妮完成签到,获得积分20
17秒前
sjx完成签到,获得积分10
19秒前
zzcc发布了新的文献求助10
20秒前
20秒前
diyochean完成签到,获得积分20
22秒前
追寻凌青完成签到 ,获得积分10
23秒前
英姑应助方格采纳,获得30
23秒前
lili李发布了新的文献求助10
24秒前
henryhc_完成签到 ,获得积分10
24秒前
我是老大应助珍妮采纳,获得10
25秒前
3kou完成签到 ,获得积分10
26秒前
我是老大应助shijin采纳,获得10
26秒前
沉静紫安完成签到,获得积分20
29秒前
700w完成签到 ,获得积分0
29秒前
高分求助中
中央政治學校研究部新政治月刊社出版之《新政治》(第二卷第四期) 1000
Hopemont Capacity Assessment Interview manual and scoring guide 1000
Classics in Total Synthesis IV: New Targets, Strategies, Methods 1000
Mantids of the euro-mediterranean area 600
【港理工学位论文】Telling the tale of health crisis response on social media : an exploration of narrative plot and commenters' co-narration 500
Mantodea of the World: Species Catalog Andrew M 500
Insecta 2. Blattodea, Mantodea, Isoptera, Grylloblattodea, Phasmatodea, Dermaptera and Embioptera 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 内科学 物理 纳米技术 计算机科学 基因 遗传学 化学工程 复合材料 免疫学 物理化学 细胞生物学 催化作用 病理
热门帖子
关注 科研通微信公众号,转发送积分 3434032
求助须知:如何正确求助?哪些是违规求助? 3031223
关于积分的说明 8941345
捐赠科研通 2719217
什么是DOI,文献DOI怎么找? 1491694
科研通“疑难数据库(出版商)”最低求助积分说明 689392
邀请新用户注册赠送积分活动 685523