细胞激素风暴
铁蛋白
发病机制
炎症
冠状病毒
2019年冠状病毒病(COVID-19)
细胞因子
免疫学
疾病
医学
生物
内科学
传染病(医学专业)
作者
Fengju Jia,Hong Liu,Shan Kang
标识
DOI:10.3389/fmolb.2021.761793
摘要
Coronavirus disease 2019 (COVID-19) is a global pandemic that has caused widespread loss of life. Notably, in this disease, severe inflammatory reactions characterized by cytokine storms are caused by severe acute respiratory syndrome coronavirus 2. The cytokine storms may promote hyper-ferritinemia which can further intensify the inflammation. Moreover, elevated ferritin levels trigger nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy, in which ferritin is degraded and iron is released. Excess iron released from ferritinophagy can promote ferroptosis and cellular damage. Therefore, we propose that NCOA4-mediated ferritinophagy can be targeted to limit the ferroptosis and prevent the multi-organ damage and severity in COVID-19 patients.
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