厚壁菌
拟杆菌
产肠毒素大肠杆菌
生物
免疫系统
乳酸菌
普雷沃菌属
微生物学
免疫
肠道菌群
双歧杆菌
免疫学
大肠杆菌
食品科学
细菌
发酵
生物化学
肠毒素
基因
遗传学
16S核糖体RNA
作者
Manrong Yu,Tiantian Meng,Wenxiang He,Hui Yu Huang,Chunming Liu,Xiaoqin Fu,Jianhua He,Yulong Yin,Dingfu Xiao
标识
DOI:10.1021/acs.jafc.1c06029
摘要
This study was conducted to investigate how chito-oligosaccharides (COSs) affect the growth performance and immune stress response and to further explain their mechanisms. A total of 32 boars that were 28 days old and three-way weaned were randomly allotted to four equal groups [CON (basal diet) group, enterotoxigenic Escherichia coli (ETEC) group, COS group, and COS*ETEC group]. The results showed that COS partially reversed the negative changes in the average daily gain and average daily feed intake caused by the ETEC challenge and thereby alleviated the increase in the feed conversion ratio. Dietary COS increased the villus length as compared with the CON group and improved the ileal morphological structure. Additionally, it increased the bacterial diversity and Bacteroidetes abundance and lowered the Firmicutes abundance and Firmicutes-to-Bacteroidetes ratio at the phylum level. COS treatment lowered the abundance of Lactobacillus, Streptococcus, and Anarovovrio in the intestines of piglets, while it increased Muribaculaceae_unclassified and Prevotella at the genus level. COS had a significant inhibitory effect on the increase in the relative expression abundance of STAT3 mRNA caused by ETEC. The IL-10 and FOXP3 mRNAs were found to be significantly lower in the COS, ETEC, and COS*ETEC groups as compared to the CON group. These results demonstrate that COS could be beneficial for improving the growth performance and attenuating ETEC-challenged intestinal inflammation via regulating microbiota and Th17/Treg balance-related immune signaling pathways.
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