Ganoderic acid A from Ganoderma lucidum protects against alcoholic liver injury through ameliorating the lipid metabolism and modulating the intestinal microbial composition

化学 肝损伤 脂质过氧化 氧化应激 丙二醛 乳酸脱氢酶 生物化学 醇脱氢酶 丙氨酸转氨酶 超氧化物歧化酶 天冬氨酸转氨酶 谷胱甘肽 药理学 内科学 生物 医学 碱性磷酸酶
作者
Xu‐Cong Lv,Qi Wu,Ying-Jia Cao,Yichen Lin,Weiling Guo,Pingfan Rao,Yanyan Zhang,Youting Chen,Lianzhong Ai,Li Ni
出处
期刊:Food & Function [Royal Society of Chemistry]
卷期号:13 (10): 5820-5837 被引量:59
标识
DOI:10.1039/d1fo03219d
摘要

Alcoholic liver injury is mainly caused by long-term excessive alcohol consumption and has become a global public threat to human health. It is well known that Ganoderma lucidum has excellent beneficial effects on liver function and lipid metabolism. The object of this study was to investigate the hepatoprotective effects of ganoderic acid A (GAA, one of the main triterpenoids in G. lucidum) against alcohol-induced liver injury and reveal the underlying mechanisms of its protective effects. The results showed that oral administration of GAA significantly inhibited the abnormal elevation of the liver index, serum total triglyceride (TG), cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in mice exposed to alcohol intake, and also significantly protected the liver against alcohol-induced excessive lipid accumulation and pathological changes. Besides, alcohol-induced oxidative stress in the liver was significantly ameliorated by the dietary intervention of GAA through decreasing the hepatic levels of lactate dehydrogenase (LDH) and malondialdehyde (MDA), and increasing hepatic activities of catalase (CAT), superoxide dismutase (SOD), alcohol dehydrogenase (ADH), aldehyde dehydrogenase (ALDH), and hepatic levels of glutathione (GSH). In addition, GAA intervention evidently ameliorated intestinal microbial disorder by markedly increasing the abundance of Muribaculaceae, Prevotellaceae, Jeotgalicoccus, Bilophila, Family_XIII_UCG_001, Aerococcus, Ruminococcaceae_UCG_005, Harryflintia, Christensenellaceae, Rumonpcpccaceae, Prevotelaceae_UCG_001, Clostridiales_vadinBB60_group, Parasutterella and Bifidobacterium, but decreasing the proportion of Lactobacillus, Burkholderia_Caballeroria_Paraburkholderia, Escherichia_Shigella and Erysipelatoclostridium. Furthermore, liver metabolomics based on UPLC-QTOF/MS demonstrated that oral administration of GAA had a significant regulatory effect on the composition of liver metabolites in mice exposed to alcohol intake, especially the levels of the biomarkers involved in the metabolic pathways of riboflavin metabolism, glycine, serine and threonine metabolism, pyruvate metabolism, glycolysis/gluconeogenesis, biosynthesis of unsaturated fatty acids, synthesis and degradation of ketone bodies, fructose and mannose metabolism. Moreover, dietary supplementation of GAA significantly regulated the hepatic mRNA levels of lipid metabolism and inflammatory response related genes. Conclusively, these findings demonstrate that GAA has beneficial effects on alleviating alcohol-induced liver injury and is expected to become a new functional food ingredient for the prevention of alcoholic liver injury.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
小蘑菇应助年轻的烨华采纳,获得10
刚刚
刚刚
zzz发布了新的文献求助10
1秒前
研友_Zzrx6Z完成签到,获得积分10
2秒前
2秒前
4秒前
4秒前
汉堡包应助NOTHING采纳,获得10
4秒前
SYLH应助科研通管家采纳,获得50
4秒前
quhayley应助科研通管家采纳,获得10
4秒前
爆米花应助科研通管家采纳,获得10
4秒前
坦率的匪应助科研通管家采纳,获得10
5秒前
田様应助科研通管家采纳,获得10
5秒前
SYLH应助科研通管家采纳,获得50
5秒前
orixero应助科研通管家采纳,获得10
5秒前
SYLH应助科研通管家采纳,获得50
5秒前
思源应助科研通管家采纳,获得10
5秒前
5秒前
隐形曼青应助科研通管家采纳,获得10
5秒前
czh应助科研通管家采纳,获得10
5秒前
赘婿应助科研通管家采纳,获得10
5秒前
华仔应助科研通管家采纳,获得10
5秒前
科研通AI2S应助科研通管家采纳,获得10
5秒前
6秒前
SYLH应助科研通管家采纳,获得50
6秒前
大模型应助科研通管家采纳,获得10
6秒前
6秒前
斯文败类应助Keyl采纳,获得10
6秒前
褪黑素应助科研通管家采纳,获得10
6秒前
完美世界应助科研通管家采纳,获得10
6秒前
6秒前
6秒前
6秒前
6秒前
6秒前
6秒前
6秒前
6秒前
6秒前
6秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3988732
求助须知:如何正确求助?哪些是违规求助? 3531027
关于积分的说明 11252281
捐赠科研通 3269732
什么是DOI,文献DOI怎么找? 1804764
邀请新用户注册赠送积分活动 881869
科研通“疑难数据库(出版商)”最低求助积分说明 809021