Plasma proteomic analysis reveals altered protein abundances in HIV‐infected patients with or without non‐Hodgkin lymphoma

淋巴瘤 发病机制 免疫学 抗体 补体系统 血液蛋白质类 免疫系统 医学 生物 病毒学 内科学
作者
Ke Zhuang,Yongxi Zhang,Pingzheng Mo,Liping Deng,Yong Jiang,Lei Yu,Fanghua Mei,Shaoxin Huang,Xi Chen,Yajun Yan,Hong‐Bin Tang,Xiangdong Li,Yong Xiong,Shuwen Wu,Hengning Ke,Xien Gui,Ke Lan
出处
期刊:Journal of Medical Virology [Wiley]
卷期号:94 (8): 3876-3889 被引量:6
标识
DOI:10.1002/jmv.27775
摘要

Abstract The identification of circulating proteins associated with acquired immunodeficiency syndrome‐related non‐Hodgkin lymphoma (AIDS‐NHL) may help in the development of promising biomarkers for screening, diagnosis, treatment, and prognosis. Here, we used quantitative liquid chromatography‐tandem mass spectrometry (LC–MS/MS) to identify differentially expressed proteins (DEPs) in plasma collected from patients with AIDS‐NHL and human immunodeficiency virus (HIV)‐infected patients without NHL (HIV + ). Proteins with a log2 (fold change) in abundance >0.26 and p < 0.05 were considered differentially abundant. In total, 84 DEPs were identified, among which 20 were further validated as potential biomarkers, with immunoglobulin and complement components being the most common proteins. Some of the proteins were further verified in a retrospective analysis of the medical records of patients in a larger cohort. These markedly altered proteins were found to mediate pathophysiological pathways that likely contribute to AIDS‐NHL pathogenesis, such as the humoral immune response, complement activation, and complement and coagulation cascades. Our findings provide a new molecular understanding of AIDS‐NHL pathogenesis and provide new evidence supporting the identification of these proteins as possible biomarkers in AIDS‐NHL.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
dyy发布了新的文献求助10
刚刚
阔达秋翠完成签到,获得积分10
1秒前
勇哥你好发布了新的文献求助10
1秒前
1秒前
小鱼儿发布了新的文献求助10
1秒前
1秒前
猇会不会发布了新的文献求助10
2秒前
2秒前
666发布了新的文献求助10
2秒前
3秒前
杨自强发布了新的文献求助10
3秒前
4秒前
Valky发布了新的文献求助10
4秒前
arong发布了新的文献求助200
4秒前
行7发布了新的文献求助10
4秒前
稳重傲柔应助伶俐书雁采纳,获得10
5秒前
5秒前
wanci应助干净的夜蓉采纳,获得10
5秒前
埋骨何须桑梓地完成签到,获得积分10
6秒前
6秒前
渝安完成签到,获得积分10
7秒前
CJ发布了新的文献求助10
7秒前
fj完成签到,获得积分10
7秒前
8秒前
善学以致用应助Growth采纳,获得10
8秒前
勇哥你好完成签到,获得积分20
8秒前
8秒前
NexusExplorer应助牛小牛采纳,获得10
8秒前
8秒前
赘婿应助风清扬采纳,获得10
8秒前
9秒前
ifanyz发布了新的文献求助10
9秒前
KYRIELIU发布了新的文献求助10
9秒前
星星发布了新的文献求助10
10秒前
啊啊啊发布了新的文献求助10
10秒前
10秒前
10秒前
清秀寄风完成签到,获得积分10
11秒前
伶俐书雁完成签到,获得积分20
11秒前
ZHQ发布了新的文献求助10
12秒前
高分求助中
Picture Books with Same-sex Parented Families: Unintentional Censorship 700
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Effective Learning and Mental Wellbeing 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3974779
求助须知:如何正确求助?哪些是违规求助? 3519193
关于积分的说明 11197417
捐赠科研通 3255311
什么是DOI,文献DOI怎么找? 1797760
邀请新用户注册赠送积分活动 877150
科研通“疑难数据库(出版商)”最低求助积分说明 806187