Plasma proteomic analysis reveals altered protein abundances in HIV‐infected patients with or without non‐Hodgkin lymphoma

淋巴瘤 发病机制 免疫学 抗体 补体系统 血液蛋白质类 免疫系统 医学 生物 病毒学 内科学
作者
Ke Zhuang,Yongxi Zhang,Pingzheng Mo,Liping Deng,Yong Jiang,Lei Yu,Fanghua Mei,Shaoxin Huang,Xi Chen,Yajun Yan,Hong‐Bin Tang,Xiangdong Li,Yong Xiong,Shuwen Wu,Hengning Ke,Xien Gui,Ke Lan
出处
期刊:Journal of Medical Virology [Wiley]
卷期号:94 (8): 3876-3889 被引量:6
标识
DOI:10.1002/jmv.27775
摘要

Abstract The identification of circulating proteins associated with acquired immunodeficiency syndrome‐related non‐Hodgkin lymphoma (AIDS‐NHL) may help in the development of promising biomarkers for screening, diagnosis, treatment, and prognosis. Here, we used quantitative liquid chromatography‐tandem mass spectrometry (LC–MS/MS) to identify differentially expressed proteins (DEPs) in plasma collected from patients with AIDS‐NHL and human immunodeficiency virus (HIV)‐infected patients without NHL (HIV + ). Proteins with a log2 (fold change) in abundance >0.26 and p < 0.05 were considered differentially abundant. In total, 84 DEPs were identified, among which 20 were further validated as potential biomarkers, with immunoglobulin and complement components being the most common proteins. Some of the proteins were further verified in a retrospective analysis of the medical records of patients in a larger cohort. These markedly altered proteins were found to mediate pathophysiological pathways that likely contribute to AIDS‐NHL pathogenesis, such as the humoral immune response, complement activation, and complement and coagulation cascades. Our findings provide a new molecular understanding of AIDS‐NHL pathogenesis and provide new evidence supporting the identification of these proteins as possible biomarkers in AIDS‐NHL.
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