Combination Treatment of Vinorelbine With Oral Cyclophosphamide or Capecitabine or Both Might Overcome Cross-resistance Against Eribulin in Advanced Breast Cancer

Okines et al.1 investigated to determine the efficacy of vinorelbine prescribed to patients after prior eribulin in advanced breast cancer (ABC) in this retrospective study. All patients who received vinorelbine after prior eribulin 2011 to 2015 and a parallel cohort of consecutive patients who received vinorelbine without prior eribulin for previously treated ABC between 2005 and 2011 were analyzed. They reported that vinorelbine was of limited benefit after prior eribulin in our study, suggesting cross-resistance.