粒体自噬
发病机制
背景(考古学)
疾病
线粒体
生物
生物信息学
自噬
神经科学
医学
细胞生物学
免疫学
遗传学
病理
古生物学
细胞凋亡
作者
Amir Ajoolabady,Mario Chiong,Sergio Lavandero,Daniel J. Klionsky,Jun Ren
标识
DOI:10.1016/j.molmed.2022.06.007
摘要
With the growing prevalence of cardiovascular disease (CVD), there is an urgent need to explore non-conventional therapeutic measures to alleviate the burden of CVD on global healthcare. Mitochondrial injury plays a cardinal role in the pathogenesis of CVD. Mitochondrial dynamics and mitophagy are essential machineries that govern mitochondrial health in cardiomyocytes in physiological and pathophysiological settings. However, with the onset and progression of CVD, homeostasis of mitophagy is disturbed through largely unknown pathological mechanisms, causing mitochondrial damage and ultimately cardiomyocyte death. In this review we decipher the dual regulatory role of mitophagy in CVD pathogenesis, summarize controversies in mitophagy, and highlight recently identified compounds capable of modulating mitophagy. We share our perspectives on future mitophagy research directions in the context of CVD.
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