自愈水凝胶
伤口愈合
PEG比率
壳聚糖
皮肤修复
弹性蛋白
聚乙二醇
药物输送
化学
药理学
生物医学工程
医学
外科
高分子化学
生物化学
病理
有机化学
财务
经济
作者
Jon Andrade del Olmo,José Marı́a Alonso,Virginia Sáez‐Martínez,Sandra Benito,Isabel Moreno,Maialen Bengoa-Larrauri,Raúl Pérez-González,José Luis Vilas‐Vilela,Leyre Pérez‐Álvarez
出处
期刊:Biomaterials advances
日期:2022-06-16
卷期号:139: 212992-212992
被引量:26
标识
DOI:10.1016/j.bioadv.2022.212992
摘要
Great efforts have been performed on the production of advanced biomaterials with the combination of self-healing and wound healing properties in implant/tissue engineering biomedical area. Inspired by this idea, chitosan (CHI) based hydrogels can be used to treat a less investigated class of harmful chronic wounds: ulcers or pressure ulcers. Thus, CHI was crosslinked with previously synthesized polyethylene glycol diacid (PEG-diacid) to obtain different CHI-PEG hydrogel formulations with high H-bonding tendency resulting in self-repair ability. Here presented results show biocompatible, antibacterial, anti-inflammatory, and self-healing CHI-PEG hydrogels with a promising future in the treatment of ulcerated wounds by a significant improvement in metabolic activity (94.51 ± 4.38 %), collagen and elastin quantities (2.12 ± 0.63 μg collagen and 4.97 ± 0.61 μg elastin per mg dermal tissue) and histological analysis. Furthermore, cefuroxime (CFX), tetracycline (TCN) and amoxicillin (AMX) antibiotics, and acetylsalicylic acid (ASA) anti-inflammatory agent were sustainedly released for enhancing antibacterial and anti-inflammatory activities of hydrogels.
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