Distinct Characteristics between Perivascular and Subcutaneous Adipose Derived Stem Cells

Adipose derived stem cells (ADSCs) can differentiate into vascular lineages and participate in vascular remodeling. Perivascular ADSCs (PV-ADSCs) draw attention due to their unique location. The heterogeneity of subcutaneous (SUB-) and abdominal ADSCs were well addressed, but PV-ADSCs’ heterogeneity hasn’t been investigated. In the present study, we applied single-cell analysis to compare SUB-ADSCs and PV-ADSCs respectively regarding their subpopulations, functions, and cell fates. We uncovered 4 subpopulations of PV-ADSCs including <i>Dpp4+</i>, <i>Col4a2+</i>/<i>Icam1+</i>, <i>Clec11a+</i>/<i>Cpe+</i> and <i>Sult1e1+</i> cells, among which <a></a><a><i>Clec11a</i>+ subpopulation</a> potentially participated in and regulated the PV-ADSCs differentiation towards a smooth muscle cell (SMC) phenotype. The present study revealed the <a></a><a>distinct characteristics </a>between PV-ADSCs and SUB-ADSCs.