Processing optimization, mechanical properties, corrosion behavior and cytocompatibility of additively manufactured Zn-0.7Li biodegradable metals

材料科学 极限抗拉强度 多孔性 合金 腐蚀 弹性模量 复合材料 抗压强度 松质骨 医学 病理
作者
Yu Qin,Hongtao Yang,Aobo Liu,Jiabao Dai,Peng Wen,Yufeng Zheng,Yun Tian,Shuang Li,Xiaogang Wang
出处
期刊:Acta Biomaterialia [Elsevier BV]
卷期号:142: 388-401 被引量:64
标识
DOI:10.1016/j.actbio.2022.01.049
摘要

Biodegradable Zn-Li alloys exhibit superior mechanical performance and favorable osteogenic capability for load-bearing bone devices. Additive manufacturing (AM) endows freedom for the fabrication of bone implants of personalized structure to satisfy patient-specific needs. In this paper, AM of Zn-Li alloys was attempted for the first-time using laser powder bed fusion (LPBF), and the fabricated samples exhibited good fusion quality and high dimensional accuracy. The processing optimization, mechanical properties, in vitro corrosion behavior and cytocompatibility were investigated by using Zn-0.7Li bulk and porous samples. The ultimate tensile strength and elastic modulus of bulk samples respectively reached 416.5 MPa and 83.3 GPa, and both were the highest among various additively manufactured Zn alloys reported so far. Porous samples achieved compressive strength (18.2 MPa) and elastic modulus (298.0 MPa), which were comparable to those of cancellous bone. Porous samples exhibited a higher corrosion rate and alleviated the problem of slow degradation of Zn-Li alloys. Nevertheless, osteoblastic cells showed a more spreading and healthier morphology when adhering to the porous samples compared to the bulk samples, thus a better cytocompatibility was confirmed. This work shows tremendous potential to precisely design and modulate biodegradable Zn alloys to fulfill clinical needs by using AM technology. This paper firstly studied processing optimization during laser powder bed fusion of Zn-Li alloy. Bulk and porous Zn-0.7Li samples in customized design were obtained with high formation quality. The tensile strength of bulk samples reached 416.5 MPa, while the compressive strength and modulus of porous samples reduced to 18.2 MPa and 298.0 MPa, comparable to those of bone. The weight loss of porous samples was roughly 5 times that of bulk samples; osteoblastic cells showed a more spreading and healthier morphology at porous samples, indicating improved biodegradation rate and cytocompatibility. This work shows tremendous potential to precisely design and modulate biodegradable Zn alloy porous scaffolds to fulfill clinical needs by using additive manufacturing technology.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Gyro完成签到,获得积分10
2秒前
隐形曼青应助lzx采纳,获得10
2秒前
3秒前
体贴紫完成签到,获得积分10
4秒前
4秒前
4秒前
5秒前
五六七完成签到,获得积分10
5秒前
5秒前
liz_发布了新的文献求助10
6秒前
新xin发布了新的文献求助10
7秒前
CodeCraft应助111111111采纳,获得10
8秒前
汉堡包应助秋天里的水采纳,获得10
9秒前
量子星尘发布了新的文献求助10
9秒前
Gyro发布了新的文献求助50
9秒前
慕青应助keyun采纳,获得10
9秒前
体贴紫发布了新的文献求助10
9秒前
10秒前
Dr.Who发布了新的文献求助10
11秒前
12秒前
深情安青应助科研通管家采纳,获得10
12秒前
彭于晏应助科研通管家采纳,获得10
12秒前
搜集达人应助科研通管家采纳,获得10
12秒前
顾矜应助科研通管家采纳,获得10
12秒前
华仔应助科研通管家采纳,获得10
12秒前
Owen应助科研通管家采纳,获得10
12秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
赘婿应助科研通管家采纳,获得10
13秒前
Ava应助科研通管家采纳,获得10
13秒前
13秒前
13秒前
Owen应助科研通管家采纳,获得10
13秒前
桐桐应助科研通管家采纳,获得10
13秒前
dali完成签到 ,获得积分10
14秒前
accept发布了新的文献求助10
15秒前
JHJ完成签到,获得积分10
15秒前
17秒前
17秒前
19秒前
belssingoo发布了新的文献求助10
20秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174