硅烷化
化学
合成子
艾伦
催化作用
试剂
SN2反应
有机化学
药物化学
组合化学
作者
Kun Guo,Qian Zeng,Alba Villar‐Yanez,Carles Bó,Arjan W. Kleij
出处
期刊:Organic Letters
[American Chemical Society]
日期:2022-01-03
卷期号:24 (2): 637-641
被引量:21
标识
DOI:10.1021/acs.orglett.1c04086
摘要
A Ni-mediated decarboxylative silylation of alkynyl cyclic carbonates used as versatile propargylic surrogates is reported affording a wide range of highly substituted 2,3- and 3,4-allenol products in good yields. The formal cross-coupling between a tentative intermediate Ni(allenyl) and the silyl reagent was further extended to enantiospecific conversions providing access to chiral allene synthons. This protocol marks the first Ni-catalyzed propargylic silylation proceeding through an SN2' manifold.
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