Potassium 2-Methyl-2-butoxide

[41233-93-6] C5H11KO (MW 126.26) InChI = 1S/C5H11O.K/c1-4-5(2,3)6;/h4H2,1-3H3;/q-1;+1 InChIKey = ZRLVQFQTCMUIRM-UHFFFAOYSA-N (strong, sterically hindered alkoxide base) Alternate Name: potassium t-pentoxide. Form Supplied in: 1.5–2.0 M solution in benzene. Solubility: sol THF, DME, aromatic hydrocarbons. Preparative Method: amber-colored 0.15–0.20 M EtCMe2OH solutions of the reagent are prepared in situ by refluxing oxide–free potassium metal in the anhydrous alcohol for 3–4 h.1 Solutions of the base which are 1.0–2.0 M in THF, benzene, or toluene are prepared by treating oil-free Potassium Hydride with an equivalent amount of anhydrous t-pentyl alcohol in the anhydrous solvent under an inert atmosphere.2 Handling, Storage, and Precautions: solutions should be handled with the same precautions that are used for solutions of t-BuOK (see Potassium tert‐Butoxide). Avoid contact with the eyes, skin, and clothing. Conduct all reactions under a dry nitrogen or argon atmosphere. In the absence of air and moisture, solutions of the base in benzene or toluene may be stored in a refrigerator for up to 1 year without significant deterioration.2b However, for critical experiments it is recommended that the reagent be freshly prepared. Use in a fume hood.