Care with intrathecal trastuzumab

I read with interest the Case Report on the use of intrathecal trastuzumab published in The Lancet Oncology because it is an uncommon method of administration for a monoclonal antibody. 1 Platini C Long J Walter S Meningeal carcinomatosis from breast cancer treated with intrathecal trastuzumab. Lancet Oncol. 2006; 7: 778-780 Summary Full Text Full Text PDF PubMed Scopus (75) Google Scholar I wish to point out a potential issue with the intrathecal administration of trastuzumab.