生物
自噬
转录组
造血
细胞生物学
祖细胞
细胞分化
川地34
干细胞
髓样
基因表达
基因
免疫学
遗传学
细胞凋亡
作者
Yan Huang,Puwen Tan,Xiaoshuang Wang,Ying Yi,Yongfei Hu,Dong Wang,Fang Wang
出处
期刊:Autophagy
[Informa]
日期:2018-02-21
卷期号:14 (3): 558-559
被引量:13
标识
DOI:10.1080/15548627.2018.1425060
摘要
Macroautophagy/autophagy plays an essential role in hematopoietic stem cell (HSC) differentiation. However, the role of autophagy during monocytic and granulocytic differentiation remains poorly understood. Hence, we first represented global transcriptomic analysis for temporal expression of autophagy genes during monocytic and granulocytic differentiation by combining RNA-Seq data with monocytic and granulocytic induction in CD34+ hematopoietic stem and progenitor cells. According to a self-organizing map (SOM) algorithm, our results show temporal expression patterns of autophagy genes during monocytic and granulocytic differentiation. More importantly, 22 autophagy genes present significantly divergent roles during monocytic and granulocytic differentiation, indicating these autophagy genes could be important factors involved in the differentiation of myeloid progenitors into monocytes and granulocytes.
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