花青素
天竺葵苷
草莓
化学
消炎药
体内
作用机理
体外
生物化学
食品科学
药理学
植物
生物
氰化物
生物技术
作者
Larissa Jeremias Duarte,Vítor Clasen Chaves,Marcus Vinícius Pereira dos Santos Nascimento,Eunice Oliveira Calvete,Mingchuan Li,Elisa Ciraolo,Alessandra Ghigo,Emilio Hirsch,Cláudia Maria Oliveira Simões,Flávio Henrique Reginatto,Eduardo Monguilhott Dalmarco
标识
DOI:10.1016/j.foodchem.2017.12.015
摘要
Fragaria x ananassa Duch., popularly called strawberry, is known for its worldwide consumption and important biological activities, and these effects are related to its high concentration of anthocyanins. Pelargonidin-3-O-glucoside (P3G) is a major anthocyanin found in strawberry, and was evaluated for its anti-inflammatory action in experimental models. The effect of strawberry extract and P3G, on leukocyte migration, exudation levels and many inflammatory mediators, was therefore evaluated in an in vivo model. An in vitro study was also carried out to characterize the effect of P3G on mitogen-activated protein kinases, and on nuclear transcript factors NF-κB and AP-1. The results revealed that the strawberry and P3G have important anti-inflammatory proprieties, and the anti-inflammatory mechanism of P3G involves the arrest of IkB-α activation and reduction in JNKMAPK phosphorylation. The results reinforce that strawberry fruits are functional foods that can act as an adjuvant in the treatment of inflammatory conditions.
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