对映选择合成
化学
有机催化
亲核细胞
催化作用
组合化学
卡宾
立体化学
有机化学
作者
Ming Zhao,Yutong Zhang,Jie Chen,Ling Zhou
标识
DOI:10.1002/ajoc.201700538
摘要
Abstract Enantioselective organocatalysis by using N‐heterocyclic carbenes (NHCs) has emerged as a powerful strategy for the construction of complex chiral molecules. Recently, remarkable advances have been made in enantioselective NHC‐catalyzed reactions that involve diverse activation intermediates, such as Breslow intermediates, homoenolate intermediates, α,β‐unsaturated acylazoliums, azolium enolates, and azolium dienolates, which are generated by the nucleophilic addition of NHCs to aldehydes. Furthermore, NHC‐catalyzed reactions that proceed through non‐covalent bonding interactions have also been developed.
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