已入深夜,您辛苦了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!祝你早点完成任务,早点休息,好梦!

Pulmonary hypertension in COPD

医学 肺动脉高压 慢性阻塞性肺病 心脏病学 内科学 重症监护医学
作者
Ari Chaouat,Robert Naeije,E Weitzenblum
出处
期刊:The European respiratory journal [European Respiratory Society]
卷期号:32 (5): 1371-1385 被引量:567
标识
DOI:10.1183/09031936.00015608
摘要

Mild-to-moderate pulmonary hypertension is a common complication of chronic obstructive pulmonary disease (COPD); such a complication is associated with increased risks of exacerbation and decreased survival. Pulmonary hypertension usually worsens during exercise, sleep and exacerbation. Pulmonary vascular remodelling in COPD is the main cause of increase in pulmonary artery pressure and is thought to result from the combined effects of hypoxia, inflammation and loss of capillaries in severe emphysema. A small proportion of COPD patients may present with "out-of-proportion" pulmonary hypertension, defined by a mean pulmonary artery pressure >35-40 mmHg (normal is no more than 20 mmHg) and a relatively preserved lung function (with low to normal arterial carbon dioxide tension) that cannot explain prominent dyspnoea and fatigue. The prevalence of out-of-proportion pulmonary hypertension in COPD is estimated to be very close to the prevalence of idiopathic pulmonary arterial hypertension. Cor pulmonale, defined as right ventricular hypertrophy and dilatation secondary to pulmonary hypertension caused by respiratory disorders, is common. More studies are needed to define the contribution of cor pulmonale to decreased exercise capacity in COPD. These studies should include improved imaging techniques and biomarkers, such as the B-type natriuretic peptide and exercise testing protocols with gas exchange measurements. The effects of drugs used in pulmonary arterial hypertension should be tested in chronic obstructive pulmonary disease patients with severe pulmonary hypertension. In the meantime, the treatment of cor pulmonale in chronic obstructive pulmonary disease continues to rest on supplemental oxygen and a variety of measures aimed at the relief of airway obstruction.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
赘婿应助梦里格斗家采纳,获得10
刚刚
丘比特应助科研通管家采纳,获得10
刚刚
欢呼洋葱应助科研通管家采纳,获得10
刚刚
隐形曼青应助科研通管家采纳,获得10
刚刚
刚刚
Akim应助科研通管家采纳,获得10
刚刚
李健应助科研通管家采纳,获得10
刚刚
科目三应助科研通管家采纳,获得10
刚刚
CipherSage应助科研通管家采纳,获得10
刚刚
刚刚
科研通AI2S应助科研通管家采纳,获得10
刚刚
科研通AI2S应助xlbn采纳,获得10
3秒前
4秒前
5秒前
6秒前
6秒前
科研通AI40应助Afterglow采纳,获得10
7秒前
骑驴找马完成签到,获得积分20
7秒前
9秒前
10秒前
11秒前
11秒前
骑驴找马发布了新的文献求助30
11秒前
12秒前
猪猪hero应助polarbear采纳,获得10
13秒前
我心飞翔完成签到 ,获得积分10
13秒前
优美巧曼完成签到,获得积分10
13秒前
lena完成签到,获得积分10
15秒前
优美巧曼发布了新的文献求助10
16秒前
Arw发布了新的文献求助10
16秒前
Antares发布了新的文献求助10
16秒前
18秒前
香蕉觅云应助椰子熟了耶采纳,获得10
18秒前
yanghong完成签到,获得积分10
18秒前
19秒前
20秒前
20秒前
21秒前
21秒前
fev123完成签到,获得积分10
22秒前
高分求助中
Genetics: From Genes to Genomes 3000
Production Logging: Theoretical and Interpretive Elements 2500
Continuum thermodynamics and material modelling 2000
Healthcare Finance: Modern Financial Analysis for Accelerating Biomedical Innovation 2000
Applications of Emerging Nanomaterials and Nanotechnology 1111
Les Mantodea de Guyane Insecta, Polyneoptera 1000
Diabetes: miniguías Asklepios 800
热门求助领域 (近24小时)
化学 医学 材料科学 生物 工程类 有机化学 生物化学 纳米技术 内科学 物理 化学工程 计算机科学 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 电极
热门帖子
关注 科研通微信公众号,转发送积分 3471228
求助须知:如何正确求助?哪些是违规求助? 3064103
关于积分的说明 9087449
捐赠科研通 2754912
什么是DOI,文献DOI怎么找? 1511625
邀请新用户注册赠送积分活动 698541
科研通“疑难数据库(出版商)”最低求助积分说明 698404