[Sjogren's syndrome-associated neuropathy].

医学 单神经病变 腓肠神经 共济失调 多发性神经病 感觉系统 周围神经病变 感觉丧失 病理 皮肤病科 麻醉
作者
Haruki Koike,Gen Sobue
出处
期刊:Brain and nerve [Igaku Shoin]
卷期号:65 (11): 1333-42 被引量:4
链接
标识
摘要

Sjogren's syndrome is a systemic autoimmune disease characterized by xerophthalmia and xerostomia; it is associated with widespread systemic visceral involvement. A wide variety of neurological complications are characteristic features of Sjogren's syndrome, of which peripheral neuropathy is a major neurological manifestation. Based on the predominant neuropathic symptoms, patients can be considered to have several forms of neuropathies, including sensory ataxic neuropathy, painful sensory neuropathy without sensory ataxia, multiple mononeuropathy, multiple cranial neuropathy, trigeminal neuropathy, autonomic neuropathy, and radiculoneuropathy. Acute or subacute onset is observed more frequently in multiple mononeuropathy and multiple cranial neuropathies, whereas disease progression is usually chronic in other forms of neuropathies. Sensory symptoms without substantial motor involvement are observed predominantly in sensory ataxic, painful sensory, trigeminal, and autonomic neuropathies. In contrast, motor impairment is apparent in multiple mononeuropathy, multiple cranial neuropathy, and radiculoneuropathy. Autonomic symptoms such as abnormal pupils and orthostatic hypotension are particularly noted in patients with sensory ataxic, painful, trigeminal, and autonomic neuropathies. Sural nerve biopsy specimens reveal predominantly large fiber loss in sensory ataxic neuropathy and predominantly small fiber loss in painful sensory neuropathy. Vasculitis is observed most frequently in multiple mononeuropathy. The autopsy findings of patients with sensory ataxic and painful neuropathies demonstrate neuronal loss in the dorsal root ganglia and sympathetic ganglia with CD8-positive cytotoxic T lymphocytes. Differential therapeutic responses to corticosteroids and intravenous immunoglobulin can be seen among the various neuropathic forms. In conclusion, the clinicopathological features of neuropathies associated with Sjogren's syndrome are highly variable. The neuropathy classification is important from a therapeutic point of view.

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
宓天问完成签到,获得积分10
1秒前
1秒前
bluesky完成签到,获得积分10
2秒前
叽里呱啦完成签到 ,获得积分10
2秒前
Distance发布了新的文献求助10
4秒前
5秒前
5秒前
专注灵凡完成签到,获得积分10
5秒前
Stageruner完成签到,获得积分10
5秒前
kiyo_v完成签到,获得积分10
5秒前
黄超超发布了新的文献求助10
6秒前
落寞剑成完成签到 ,获得积分10
6秒前
七子完成签到,获得积分10
6秒前
klio完成签到 ,获得积分10
7秒前
zzx396完成签到,获得积分0
8秒前
one完成签到 ,获得积分10
9秒前
十五完成签到,获得积分10
9秒前
ptjam完成签到 ,获得积分10
10秒前
神勇的晟睿完成签到 ,获得积分10
11秒前
11秒前
曾珍完成签到 ,获得积分10
11秒前
Muhi完成签到,获得积分10
11秒前
11秒前
自带蓝牙的土豆完成签到 ,获得积分10
12秒前
青羽落霞完成签到 ,获得积分10
13秒前
抹颜完成签到,获得积分10
14秒前
量子星尘发布了新的文献求助10
18秒前
胡图图完成签到,获得积分10
19秒前
睡觉大王完成签到 ,获得积分10
20秒前
21秒前
21秒前
22秒前
22秒前
27秒前
玩命的十三完成签到 ,获得积分10
27秒前
寂寞的诗云完成签到,获得积分10
29秒前
我爱科研完成签到 ,获得积分10
29秒前
30秒前
Bin_Liu发布了新的文献求助10
31秒前
She完成签到,获得积分10
31秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022