沟道视紫红质
光遗传学
神经科学
兴奋性突触后电位
神经传递
系统神经科学
生物神经网络
生物
计算机科学
抑制性突触后电位
毫秒
物理
中枢神经系统
生物化学
受体
髓鞘
天文
少突胶质细胞
作者
Edward S. Boyden,Feng Zhang,Ernst Bamberg,Georg Nagel,Karl Deisseroth
摘要
Temporally precise, noninvasive control of activity in well-defined neuronal populations is a long-sought goal of systems neuroscience. We adapted for this purpose the naturally occurring algal protein Channelrhodopsin-2, a rapidly gated light-sensitive cation channel, by using lentiviral gene delivery in combination with high-speed optical switching to photostimulate mammalian neurons. We demonstrate reliable, millisecond-timescale control of neuronal spiking, as well as control of excitatory and inhibitory synaptic transmission. This technology allows the use of light to alter neural processing at the level of single spikes and synaptic events, yielding a widely applicable tool for neuroscientists and biomedical engineers.
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