Impact of pretreatment thrombocytosis on survival in primary breast cancer

血小板增多症 医学 乳腺癌 内科学 比例危险模型 肿瘤科 癌症 胃肠病学 回顾性队列研究 生存分析 血小板
作者
Susanne Taucher,Andreas Salat,Michael Gnant,W. Kwasny,Brigitte Mlineritsch,Rainer-Christian Menzel,Marianne Schmid,M.G. Smola,M. Stierer,Christoph Tausch,A. Galid,Günther Steger,Raimund Jakesz
出处
期刊:Thrombosis and Haemostasis [Thieme Medical Publishers (Germany)]
卷期号:89 (06): 1098-1106 被引量:142
标识
DOI:10.1055/s-0037-1613413
摘要

Summary Platelet count has been reported to have predictive value in various cancer entities. In the case of breast cancer, evidence about involvement of platelets is still incomplete. Our objective was to assess the influence of pretreatment thrombocytosis on survival and establish its prognostic relevance for breast cancer patients. We performed a retrospective, multivariate analysis of 4,300 patients with early-stage breast cancer. All subjects participated in one of five prospective, randomized, multicenter trials conducted by the Austrian Breast and Colorectal Cancer Study Group. Thrombocytosis was defined as a platelet count exceeding 400 G/L. Median follow-up was 52 months. Univariate and multiple Cox regression models were calculated for overall survival (OS), breast cancer-related survival and disease-free survival (DFS). Pretreatment thrombocytosis was observed in 161 patients (3.7%). Estimated median OS, breast cancer-related survival and DFS for patients with versus those without thrombocytosis was 71.0 versus 99.5, 72.0 versus 100.9, and 80.4 versus 88.4 months, respectively (p = 0.0054, p = 0.0095, p = 0.0199). A multiple Cox regression model including tumor and nodal status, grading, age, hormone receptor status and pretreatment thrombocytosis identified pretreatment thrombocytosis as an independent predictive factor for OS (p = 0.0064) and breast cancer-related survival (p = 0.0162). Multivariate analysis failed to identify pretreatment thrombocytosis as an independent risk factor for DFS (p = 0.1355). In our retrospective study, elevated platelet counts at time of diagnosis were associated with poor prognosis in breast cancer. We hypothesize that platelets may contribute to the patho-physiology of hematogenous metastasis.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
kyJYbs完成签到,获得积分10
刚刚
信远征发布了新的文献求助10
刚刚
小王发布了新的文献求助10
刚刚
刚刚
lwl666完成签到,获得积分10
1秒前
2秒前
1762571452完成签到,获得积分10
4秒前
548完成签到,获得积分10
4秒前
薄年完成签到,获得积分10
6秒前
付小源完成签到,获得积分10
7秒前
票子完成签到,获得积分10
7秒前
酷炫迎波完成签到,获得积分10
9秒前
沐晨浠完成签到,获得积分10
9秒前
tcf完成签到,获得积分10
10秒前
MrSong完成签到,获得积分10
11秒前
豆浆来点蒜泥完成签到,获得积分0
12秒前
14秒前
15秒前
可燃冰完成签到,获得积分10
16秒前
16秒前
黄石完成签到,获得积分10
16秒前
Justtry完成签到,获得积分10
16秒前
Sunshine完成签到 ,获得积分10
17秒前
虚心的仙人掌完成签到,获得积分0
18秒前
信远征完成签到,获得积分10
18秒前
落尘完成签到,获得积分10
19秒前
务实小鸽子完成签到 ,获得积分10
20秒前
20秒前
王小磊发布了新的文献求助10
20秒前
Iwan完成签到,获得积分10
20秒前
小蘑菇应助LIUYONG采纳,获得10
24秒前
大气的山彤完成签到,获得积分10
25秒前
苏木发布了新的文献求助10
25秒前
Yep0672完成签到,获得积分10
25秒前
小王发布了新的文献求助10
26秒前
26秒前
27秒前
27秒前
27秒前
粥粥完成签到,获得积分10
28秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038388
求助须知:如何正确求助?哪些是违规求助? 3576106
关于积分的说明 11374447
捐赠科研通 3305798
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029