Densitometer-Specific Differences in the Correlation Between Body Mass Index and Lumbar Spine Trabecular Bone Score

密度计 医学 骨小梁评分 骨矿物 体质指数 密度测定 核医学 腰椎 皮尔逊积矩相关系数 腰椎 骨质疏松症 妇科 内科学 定量计算机断层扫描 外科 数学 统计 物理 量子力学
作者
Gillian Mazzetti,Claudie Berger,William D. Leslie,Didier Hans,Lisa Langsetmo,David A. Hanley,Christopher S. Kovacs,J. C. Prior,Stéphanie Kaiser,Kelly Davison,Robert G. Josse,Αλεξάνδρα Παπαϊωάννου,J. Adachi,David Goltzman,Suzanne N. Morin
出处
期刊:Journal of Clinical Densitometry [Elsevier BV]
卷期号:20 (2): 233-238 被引量:43
标识
DOI:10.1016/j.jocd.2016.11.003
摘要

Trabecular bone score (TBS) is a gray-level texture measure derived from lumbar spine dual-energy X-ray absorptiometry (DXA) images that predicts fractures independent of bone mineral density (BMD). Increased abdominal soft tissue in individuals with elevated body mass index (BMI) absorbs more X-rays during image acquisition for BMD measurement and must be accommodated by the TBS algorithm. We aimed to determine if the relationship between BMI and TBS varied between 2 major manufacturers' densitometers, because different densitometers accommodate soft tissues differently. We identified 1919 women and 811 men, participants of the Canadian Multicentre Osteoporosis Study, aged ≥40 yr with lumbar spine DXA scans acquired on GE Lunar (4 centers) or Hologic (3 centers) densitometers at year 10 of follow-up. TBS was calculated for L1-L4 (TBS iNsight® software, version 2.1). A significant negative correlation between TBS and BMI was observed when TBS measurements were performed on Hologic densitometers in men (Pearson r = -0.36, p <0.0001) and in women (Pearson r = -0.33, p <0.0001); significant correlations were not seen when TBS was measured on GE Lunar densitometers (Pearson r = 0.00 in men, Pearson r = -0.02 in women). Age-adjusted linear regression models confirmed significant interactions between BMI and densitometer manufacturer for both men and women (p < 0.0001). In contrast, comparable positive correlations were observed between BMD and BMI on both Hologic and GE Lunar densitometers in men and women. In conclusion, BMI significantly affects TBS values in men and women when measured on Hologic but not GE Lunar densitometers. This finding has implications for clinical and research applications of TBS, especially when TBS is measured sequentially on DXA densitometers from different manufacturers or when results from different machines are pooled for analysis.
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