聚合物
纳米尺度
材料科学
卟啉
纳米技术
多孔性
金属有机骨架
纳米复合材料
多孔介质
化学工程
金属
化学
有机化学
吸附
复合材料
工程类
冶金
作者
Xiaohua Zheng,Lei Wang,Qing Pei,Shasha He,Shi Liu,Zhigang Xie
标识
DOI:10.1021/acs.chemmater.7b00228
摘要
The limitation for the biomedical application of porous organic polymers (POPs) is the big size and poor dispersibility in aqueous media. Herein, a nanoscale metal–organic framework (MOF)@POP composite, named UNM, has been synthesized by epitaxial growth of the photoactive porphyrin-POPs (H2P-POP) on the outer surface of amine containing UiO-66 (UiO-AM). After the growth of POPs, the crystallization, pore structure, and size distribution of UNM are retained well. The formed UNM possesses a small size of less than 200 nm and could be internalized by cancer cells. Such light-activated UNM exhibits efficient ability to generate 1O2 under various experimental conditions, which can be further applied for PDT efficacy. The present work demonstrates the great potential of nanoscale porous polymers in biomedical fields and cancer treatment.
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