三角线
马尿酸
牛磺酸
尿
新陈代谢
医学
富马酸
琥珀酸
化学
三甲胺
生物化学
尿素
柠檬酸
谷氨酰胺
内分泌学
肌酐
内科学
氨基酸
作者
Yongquan Zheng,Xiaoqian Zhang,Jiuxia Chen,Qi Tony Zhou,Hongchang Gao
出处
期刊:PubMed
日期:2018-12-25
卷期号:47 (6): 636-642
被引量:2
标识
DOI:10.3785/j.issn.1008-9292.2018.12.12
摘要
To investigate the metabolic profiles of urine from APP/PS1 mice with early-stage Alzheimer's disease (AD).Urine samples were collected from 13 APP/PS1 mice of 16 weeks and 15 wild-type mice. 1H-NMR spectroscopy was acquired with a one-dimensional NOESY pulse sequence, and the integral values were imported to SIMCA-P+12.0 software for analysis.The metabonomic analysis showed that the metabolic profiles of the APP/PS1 mice were significantly different from that of age-matched wild-type mice. The levels of 3-hydroxybutyrate, 2-hydroxybutyrate, succinic acid, 2-ketoglutaric acid, citric acid, cis-aconitic acid, fumaric acid decreased, and those of acetic acid, trimethylamine, taurine, creatinine, hippuric acid, formic acid, trigonelline, urea increased (all P<0.05).Metabolic pathways including glucose metabolism and methylamine metabolism may be involved in the pathogenesis of early AD.
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