Synthesis of MoSe2/CoSe2 Nanosheets for NIR‐Enhanced Chemodynamic Therapy via Synergistic In‐Situ H2O2 Production and Activation

Abstract Currently, the limited intratumoral H 2 O 2 level restricts the development of chemodynamic therapy (CDT). Herein, MoSe 2 /CoSe 2 @PEG nanosheets are prepared to reveal NIR‐photocatalytic H 2 O 2 generation to insure the intracellular H 2 O 2 supplement. The formation mechanism is investigated, showing the dissolved O 2 and photo‐excited electrons to determine H 2 O 2 production via sequential single‐electron transfer process. The experimental data and density functional theory calculation further display their typical‐II heterostructure, which possesses the effective charge separation and nearly four times H 2 O 2 generation than MoSe 2 @PEG. In addition, the nanocomposites also reveal the peroxidase/catalase activity, making the in‐situ H 2 O 2 activation and ·OH generation. And, the O 2 production derived from catalase‐mimic activity not only relieves hypoxia but also offers the source for H 2 O 2 production. Because of the decreased resistance for charge transfer, MoSe 2 /CoSe 2 @PEGs also reveal more than three times enzyme‐activity for MoSe 2 @PEG. With the narrow band gap and high NIR‐harvest, MoSe 2 /CoSe 2 @PEG exhibits the great photothermal converting ability (62.5%). MoSe 2 /CoSe 2 @PEG reveals the novel biodegradation, and most of them can be eliminated via urine and feces within 2 weeks. Here, the computed tomography/magnetic resonance imaging/photothermal imaging and the synergistic photothermal therapy/CDT treatments further make sure potential application on anticancer.