材料科学
马来酸酐
离解(化学)
基质(水族馆)
辐照
化学工程
嫁接
纳米技术
间充质干细胞
表面改性
化学
有机化学
聚合物
复合材料
海洋学
物理
地质学
工程类
核物理学
细胞生物学
生物
共聚物
作者
Jun Bai,Xingang Zuo,Xue Feng,Yunfeng Sun,Qunzi Ge,Xuemei Wang,Changyou Gao
标识
DOI:10.1021/acsami.9b11536
摘要
Stimuli-responsive biomaterials supply a promising solution to adapt to the complex physiological environment for different biomedical applications. In this study, a dynamic UV-triggered pH-responsive biosurface was constructed on titania nanotubes (TNTs) by loading photoacid generators, diphenyliodonium chloride, into the nanotubes, and grafting 2,3-dimethyl maleic anhydride (DMMA)-modified hyperbranched poly(l-lysine) (HBPLL) onto the surface. The local acidity was dramatically enhanced by UV irradiation for only 30 s, leading to the dissociation of DMMA and thereby the transformation of surface chemistry from negatively charged caboxyl groups to positively charged amino groups. The TNTs–HBPLL–DMMA substrate could better promote proliferation and spreading of rat bone mesenchymal stem cells (rBMSCs) after UV irradiation. The osteogenic differentiation of rBMSCs was enhanced because of the charge reversal in combination with the titania-based substrates.
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