Is exercise a senolytic medicine? A systematic review

生物 衰老 病态的 疾病 生物信息学 生理学 癌症研究 医学 病理 细胞生物学
作者
Xiang‐Ke Chen,Zhen‐Ni Yi,Gordon Tin‐Chun Wong,Kazi Md Mahmudul Hasan,Joseph Kwan,Alvin Chun‐Hang,Raymond Chuen‐Chung Chang
出处
期刊:Aging Cell [Wiley]
卷期号:20 (1) 被引量:56
标识
DOI:10.1111/acel.13294
摘要

Abstract Cellular senescence, a state of irreversible growth arrest triggered by various stressors, engages in a category of pathological processes, whereby senescent cells accumulate in mitotic tissues. Senolytics as novel medicine against aging and various diseases through the elimination of senescent cells has emerged rapidly in recent years. Exercise is a potent anti‐aging and anti‐chronic disease medicine, which has shown the capacity to lower the markers of cellular senescence over the past decade. However, whether exercise is a senolytic medicine for aging and various diseases remains unclear. Here, we have conducted a systematic review of the published literature studying the senolytic effects of exercise or physical activity on senescent cells under various states in both human and animal models. Exercise can reduce the markers of senescent cells in healthy humans, while it lowered the markers of senescent cells in obese but not healthy animals. The discrepancy between human and animal studies may be due to the relatively small volume of research and the variations in markers of senescent cells, types of cells/tissues, and health conditions. These findings suggest that exercise has senolytic properties under certain conditions, which warrant further investigations.
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