色胺
化学
分子内力
胺气处理
区域选择性
表面改性
催化作用
产量(工程)
基质(水族馆)
功能群
组合化学
立体化学
药物化学
色胺
有机化学
物理化学
冶金
材料科学
聚合物
地质学
海洋学
生物化学
作者
Sixi Wang,Bin Yu,Hong‐Min Liu
出处
期刊:Organic Letters
[American Chemical Society]
日期:2020-12-17
卷期号:23 (1): 42-48
被引量:9
标识
DOI:10.1021/acs.orglett.0c03668
摘要
The free amine-directed C-H functionalization reactions are challenging and mainly restricted to bulky amines. In this work, we report the nonsteric NH2-directed Pd(II)-catalyzed intramolecular C(sp2)-H arylation of tryptamines, which enables the efficient, gram-scale, and regioselective synthesis of versatile 2-aryltryptamines (35 examples, up to 98% yield). This approach broadens the substrate scope of the free amine-directed C-H functionalization, not limited to bulky amine substrates. Late-stage elaborations of 2-aryltryptamines achieve the divergent construction of the complex core structures that are prevalent in highly valuable natural products such as aurantioclavine, chimonanthine, and phalarine.
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