JAK-STAT信号通路
鲁索利替尼
STAT1
医学
肿瘤微环境
酪氨酸激酶
PI3K/AKT/mTOR通路
状态5
胶质瘤
胶质母细胞瘤
作者
Alexander Ou,Martina Ott,Dexing Fang,Amy B. Heimberger
出处
期刊:Cancers
[MDPI AG]
日期:2021-01-24
卷期号:13 (3): 437-437
被引量:58
标识
DOI:10.3390/cancers13030437
摘要
Glioblastoma remains one of the deadliest and treatment-refractory human malignancies in large part due to its diffusely infiltrative nature, molecular heterogeneity, and capacity for immune escape. The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway contributes substantively to a wide variety of protumorigenic functions, including proliferation, anti-apoptosis, angiogenesis, stem cell maintenance, and immune suppression. We review the current state of knowledge regarding the biological role of JAK/STAT signaling in glioblastoma, therapeutic strategies, and future directions for the field.
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