Methods and quality control challenges for complement analysis

The complement system is a complex protein network. Complement is important in disease severity and response to therapy. This review summarizes recent advances on the role of complement analysis in complement function or activity, complement factors concentrations, complement activation products, complement autoantibody and genetic analysis. And it also focuses on pre-analytical and post-analytical quality control for complement analysis.(Chin J Lab Med, 2017, 40: 648-651) Key words: Complement system proteins; Complement activation; Autoantibodies; Quality control