脂肪性肝炎
脂肪肝
医学
脂肪变性
内科学
胃肠病学
促炎细胞因子
炎症
非酒精性脂肪肝
肿瘤坏死因子α
疾病
作者
Abolghasem Hadinia,Amir Hossein Doustimotlagh,Hamid Reza Goodarzi,Arash Arya,Mojtaba Jafarinia
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2019-12-01
卷期号:16 (4): 327-333
被引量:21
标识
DOI:10.22034/iji.2019.80284
摘要
Pro-inflammatory cytokines are associated with systemic inflammatory responses.To investigate the levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNF-α) in patients with non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH) compared to healthy individuals.This case-control study was conducted on 30 patients with NAFL, 30 patients with NASH, and 30 healthy volunteers. The plasma level of IL-1β, IL-6, and TNF-α were determined by ELISA, and biochemical parameters were measured using colorimetric methods.IL-1β and IL-6 levels were significantly higher in patients with NASH compared with NAFL and control group. However, TNF-α levels had no significant variations in NAFL and NASH patients compared to the control group (p=0.903 and p=0.960, respectively).Results showed that the levels of ALT activity and pro-inflammatory cytokines were higher in patients with NASH compared to control and NAFL subjects; Therefore, steatosis and inflammation develop as a result of excessive pro-inflammatory factors in NASH.
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