Risk factors for 5-year mortality in a cohort of elderly patients with sarcopenia

肌萎缩 医学 比例危险模型 内科学 逻辑回归 危险系数 体质指数 队列 置信区间
作者
Hanan Abbas,Simone Perna,Afzal Shah,Mariam Al‐Mannai,Clara Gasparri,Vittoria Infantino,E. Cereda,Gabriella Peroni,Antonella Riva,Giovanna Petrangolini,Mariangela Rondanelli
出处
期刊:Experimental Gerontology [Elsevier]
卷期号:136: 110944-110944 被引量:7
标识
DOI:10.1016/j.exger.2020.110944
摘要

The association between multiple risk factors and the mortality of sarcopenic patients has not been studied. This study's aim is to report the prevalence of sarcopenia among a sample of Italian hospitalized older adults, describe the physical function, body fat composition, cognitive, inflammatory and nutritional status of sarcopenic compared with non-sarcopenic subjects, and determine the risk factors associated with mortality in sarcopenic patients. A total of 462 patients were enrolled and followed up for a period of 5 years. Sarcopenia was diagnosed according to the EWGSOP2 criteria. Factors associated with sarcopenia were identified with linear regression analysis. Logistic regression was applied to explore the association between the risk factors and mortality in sarcopenic subjects. Survival analyses and predictors of mortality were identified using Kaplan-Meier and Cox regression. The prevalence of sarcopenia was 33.5%. Linear regression showed that sarcopenia was associated with Barthel index (B −9.63, p0.004), BMI (B −3.19, p<0.001) and android fat (B 1.85, p0.004). Of these factors, only the number of co-morbidities (OR 1.394 C95% 1.023–1.862 p 0.025) and MMSE scores (OR 0.857 C95% 0.79–0.930 p <0.001) were associated with mortality in sarcopenia. Kaplan-Meier and the log-rank tests showed the negative prognostic effect of low BMI (p0.007), albumin (p<0.001) and Barthel index (p 0.018). The Cox regression showed that mortality hazard is reduced with BMI >24.9 (HR 0.287 C95% 0.095–0.866 p 0.027). Sarcopenia is associated with low physical function and BMI but higher android fat. Low Barthel, BMI and albumin can significantly decrease the survival rate in sarcopenic patients. Whereas BMI >24.9 is associated with lower mortality hazard.
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