静脉注射
血管生成
肿瘤微环境
转移
趋化因子
基质金属蛋白酶
免疫系统
生物
癌症研究
外渗
肿瘤进展
巨噬细胞极化
免疫学
巨噬细胞
癌症
体外
生物化学
遗传学
作者
Luo‐Qin Fu,Wei Du,Mao-Hua Cai,Jiyong Yao,Yuanyuan Zhao,Xiaozhou Mou
标识
DOI:10.1016/j.cellimm.2020.104119
摘要
Tumor associated macrophages (TAMs) are the most frequent immune cells within tumor microenvironment (TME). There is growing evidence that TAMs are involved in tumor progression via multiple mechanisms. TAMs create an immunosuppressive TME by producing growth factors, chemokines, and cytokines which modulate recruitment of immune cells and inhibit anti-tumor responses. They also serve as angiogenesis promoting cells by production of pro-angiogenic factors and matrix metalloproteinases (MMPs) and vascular constructing which guarantee supplying oxygen and nutrients to solid tumor cells. Furthermore, TAMs play important functions in tumor metastasis through contributing to invasion, extravasation, survival, intravasation, and colonization of tumor cells. In this review, we summarized macrophage classification, TAMs polarization, and mechanisms underlying TAM-promoting angiogenesis and metastasis.
科研通智能强力驱动
Strongly Powered by AbleSci AI