纳米载体
鼻腔给药
现状
医学
药物输送
药理学
胶质母细胞瘤
重症监护医学
药品
纳米技术
癌症研究
市场经济
经济
材料科学
作者
Fakhara Sabir,Ruba Ismail,Ildikó Csóka
标识
DOI:10.1016/j.drudis.2019.10.005
摘要
Glioblastoma multiforme (GBM) is one of the most devastating and deadly types of tumor. Among all the present treatment strategies, the utmost prerequisite is prolonged intervention at the malignant site. The blood–brain barrier (BBB) is the bottleneck in the delivery of anti-GBM drugs and invasive treatment comes with many pitfalls. This review will discuss the potential of embedding antitumor drugs into nanocarriers for intranasal delivery. Additionally, it emphasizes the significance of applying quality by design (QbD) methodology from the early development stages to ensure the high quality, safety and efficacy of the developed carrier system.
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