核糖分型
多位点序列分型
打字
生物
分子流行病学
脉冲场凝胶电泳
梭菌纲
基因座(遗传学)
流行病学
遗传学
微生物学
聚合酶链反应
基因型
基因
医学
内科学
作者
Adrián Martínez-Meléndez,Rayo Morfín‐Otero,Licet Villarreal-Treviño,Simon D. Baines,Adrián Camacho-Ortíz,Elvira Garza‐González
标识
DOI:10.1016/j.mimet.2020.105974
摘要
There has been an increase in the incidence and severity of Clostridioides difficile infection (CDI) worldwide, and strategies to control, monitor, and diminish the associated morbidity and mortality have been developed. Several typing methods have been used for typing of isolates and studying the epidemiology of CDI; serotyping was the first typing method, but then was replaced by pulsed-field gel electrophoresis (PFGE). PCR ribotyping is now the gold standard method; however, multi locus sequence typing (MLST) schemes have been developed. New sequencing technologies have allowed comparing whole bacterial genomes to address genetic relatedness with a high level of resolution and discriminatory power to distinguish between closely related strains. Here, we review the most frequent C. difficile ribotypes reported worldwide, with a focus on their epidemiology and genetic characteristics.
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