小角X射线散射
层状结构
六角相
材料科学
相(物质)
六方晶系
共聚物
甘油
相变
偏振光显微镜
色谱法
化学工程
散射
化学
结晶学
有机化学
复合材料
光学
聚合物
物理
工程类
量子力学
作者
Spomenka Milak,Angela Chemelli,Otto Glatter,Andreas Zimmer
出处
期刊:Pharmaceutics
[MDPI AG]
日期:2020-06-08
卷期号:12 (6): 521-521
被引量:3
标识
DOI:10.3390/pharmaceutics12060521
摘要
The influence of two tuning agents, polyglycerol ester (PE) and triblock copolymer (TC), on the properties of glycerol monooleate (MO) liquid crystalline phase (LCP) was investigated to achieve the therapeutic concentration of vancomycin hydrochloride (VHCl) into the eye, topically during 60 min (1 h) and intravitreally during 2880 min (48 h). Different techniques were used to elucidate the impact of surfactants on the structure of the LCP: polarized light microscopy (PLM), small-angle X-ray scattering (SAXS), and in vitro release tests I and II (simulating local and intravitreal application in the eye). The structure analysis by SAXS depicts that the inclusion of PE into the MO LCP provided partial transition of a hexagonal phase into a lamellar phase, and TC induced a partial transition of a hexagonal phase into an LCP which identification was difficult. The LCP modulated with PE and TC demonstrated different VHCl's release patterns and were evaluated by comparing our release data with the literature data. The comparison indicated that the LCP modulated with 30%
科研通智能强力驱动
Strongly Powered by AbleSci AI