S1615 Helicobacter pylori CagA Increases C-Jun Expression By the Orphan Nuclear Receptor Shp Induction in Gastritis

mucus was measured by the area ratio (%).Tissue levels of myeloperoxidase (MPO), glutathione and lipid peroxidation (LPO) in the frozen gastric mucosa were determined.Results: Gastric mucosal atrophy was observed by giving 0.1% ammonia water ad libitum for 6 weeks.The course of atrophy was similar to that of human atrophic gastritis due to Helicobacter pylori infection.Furthermore, both superficial and deep mucus significantly decreased.On the contrary, coadministration of GGA, one of gastric mucosal protective agents, inhibited decrease in gastric mucus as well as gastric mucosal atrophy in the 0.1% ammonia water group.In that way, MPO activity, which is an index of tissue disorders in gastric mucosa, and LPO activities were significantly increased due to access to ammonia water, while GGA suppressed these activities.Conclusion: It was suggested that significant elevations in MPO and LPO activities were associated with gastric mucosal atrophy induced by long-term administration of ammonia water, and that the anti-ulcer agent geranylgeranylacetone preserved the intra-gastric mucous quantity while inhibiting the gastric mucosal atrophy without the elevations in MPO and LPO activities.