Transplantation of cultured thymic fragments. II. Results in nude mice.

移植 抗体 生物 刀豆蛋白A 免疫学 男科 拉顿 C57BL/6型 医学 内科学 体外 生物化学
作者
Robert Hong,H. Schulte-Wissermann,E Jarrett-Toth,Sheldon D. Horowitz,Dean D. Manning
出处
期刊:Journal of Experimental Medicine [The Rockefeller University Press]
卷期号:149 (2): 398-415 被引量:61
标识
DOI:10.1084/jem.149.2.398
摘要

Nine nude mice were transplanted with cultured thymic fragments derived from syngeneic (three recipients) or allogeneic (six recipients) sources. All transplanted mice survived for periods of up to 8-10 mo thereafter, at which time they were sacrificed. Weight gain had been progressive and the animals were in excellent health. Four nontransplanted littermates housed in the same cages died at the age of 4 mo. In the nontransplanted mice, the usual deficits of T and B cells were observed. In transplanted mice, normalization of IgG1 and IgA levels as well as IgG antibodies to sheep erythrocytes and precipitating antibodies to rabbit serum occurred. Lymphocyte counts and Thy-1 bearing cells increased to approximately 50% of normal values. Proliferative responses to phytohemagglutinin and concanavalin A, mixed leukocyte reactivity, and cell-mediated lympholysis were variably restored from approximately 10-100% of normal. Attained responses were the same in recipients of syngeneic or allogeneic tissues and these, in turn, were equal or superior to responses measured in animals transplanted with whole noncultured thymuses. Skin grafts from third party donors were vigorously rejected, whereas those derived from second party (allogeneic thymus donor strain) may have been accepted or slowly rejected. Cultured thymic fragments, consisting primarily of epithelial elements, can effectively repair the thymic deficiency of nude mice. Experiments to date do not indicate that syngeneic tissues enjoy an advantage over allogeneic grafts in this restoration procedure.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Hello应助平常的雁凡采纳,获得10
刚刚
831143完成签到 ,获得积分0
1秒前
1秒前
paleo-地质给paleo-地质的求助进行了留言
1秒前
要减肥的砖头完成签到,获得积分10
2秒前
Leo完成签到,获得积分10
4秒前
wsq完成签到 ,获得积分10
4秒前
LU完成签到,获得积分10
5秒前
Kabutack发布了新的文献求助10
7秒前
7秒前
碧蓝的不言关注了科研通微信公众号
7秒前
8秒前
北过完成签到,获得积分10
8秒前
科研通AI2S应助小菜鸡采纳,获得10
9秒前
已忘的人完成签到,获得积分10
9秒前
11完成签到,获得积分10
10秒前
10秒前
YuGe完成签到,获得积分10
10秒前
yujd完成签到,获得积分10
12秒前
林家小弟完成签到,获得积分10
12秒前
Along完成签到,获得积分10
12秒前
调皮蛋完成签到,获得积分10
12秒前
浪费完成签到 ,获得积分10
13秒前
山月完成签到,获得积分20
13秒前
Dream发布了新的文献求助30
13秒前
汪少侠完成签到,获得积分10
13秒前
复杂谷蓝完成签到 ,获得积分10
14秒前
14秒前
15秒前
成就映秋完成签到,获得积分10
16秒前
HCLonely应助清新的听南采纳,获得10
16秒前
宁宁完成签到 ,获得积分10
17秒前
Bingtao_Lian完成签到 ,获得积分10
17秒前
二斤瓜子完成签到,获得积分10
17秒前
Akashi发布了新的文献求助10
17秒前
。。完成签到 ,获得积分10
18秒前
谦让黎云完成签到,获得积分10
18秒前
qwerl完成签到,获得积分10
18秒前
Kabutack完成签到,获得积分10
19秒前
xlong完成签到,获得积分10
20秒前
高分求助中
Licensing Deals in Pharmaceuticals 2019-2024 3000
Cognitive Paradigms in Knowledge Organisation 2000
Effect of reactor temperature on FCC yield 2000
Introduction to Spectroscopic Ellipsometry of Thin Film Materials Instrumentation, Data Analysis, and Applications 1200
How Maoism Was Made: Reconstructing China, 1949-1965 800
Medical technology industry in China 600
Shining Light on the Dark Side of Personality 400
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3311408
求助须知:如何正确求助?哪些是违规求助? 2944145
关于积分的说明 8517601
捐赠科研通 2619516
什么是DOI,文献DOI怎么找? 1432421
科研通“疑难数据库(出版商)”最低求助积分说明 664655
邀请新用户注册赠送积分活动 649867