Lipoprotein(a) is an important factor to determine coronary artery plaque morphology in patients with acute myocardial infarction

医学 血管内超声 病变 心肌梗塞 脂蛋白(a) 动脉 易损斑块 内科学 冠状动脉粥样硬化 血管造影 心脏病学 纤维帽 脂蛋白 放射科 冠状动脉疾病 病理 胆固醇
作者
Hiroyuki Hikita,Takatoshi Shigeta,Keisuke Kojima,Yuki Oosaka,Keiichi Hishikari,Naohiko Kawaguchi,Emiko Nakashima,Tomoyo Sugiyama,Daiki Akiyama,Tetsuo Kamiishi,Shigeki Kimura,Yoshihide Takahashi,Taishi Kuwahara,Akira Sato,Atsushi Takahashi,Mitsuaki Isobe
出处
期刊:Coronary Artery Disease [Lippincott Williams & Wilkins]
卷期号:24 (5): 381-385 被引量:15
标识
DOI:10.1097/mca.0b013e3283622329
摘要

Lipoprotein(a) [Lp(a)] can influence the development and disruption of atherosclerotic plaques through its effect on lipid accumulation. The purpose of this study was to evaluate the relationship between serum Lp(a) levels and plaque morphology of an infarct-related lesion and non-infarct-related lesion of the coronary artery in acute myocardial infarction (AMI).Coronary plaque morphology was evaluated in 68 patients (age 62.1±12.1 years, mean±SD; men n=58, women n=10) with AMI by intravascular ultrasound with radiofrequency data analysis before coronary intervention and by 64-slice computed tomography angiography within 2 weeks. Patients were divided into a group with an Lp(a) level of 25 mg/dl or more (n=20) and a group with an Lp(a) level of less than 25 mg/dl (n=48). Intravascular ultrasound with radiofrequency data analysis identified four types of plaque components at the infarct-related lesion: fibrous, fibrofatty, dense calcium, and necrotic core. The necrotic core component was significantly larger in the group with an Lp(a) level of 25 mg/dl or more than in the group with an Lp(a) level of less than 25 mg/dl (27.6±8.0 vs. 15.7±10.0%, P=0.0001). Coronary plaques were classified as calcified plaques, noncalcified plaques, mixed plaques, and low-attenuation plaques on 64-slice computed tomography angiography. Computed tomography indicated that the group with an Lp(a) level of 25 mg/dl or more had a greater number of total plaques, noncalcified plaques, and low-attenuation plaques in whole coronary arteries than did the group with an Lp(a) level of less than 25 mg/dl (5.3±1.8 vs. 3.7±2.2, P=0.0061; 4.0±2.0 vs. 1.2±1.3, P=0.0001; 2.2±2.1 vs. 0.5±0.7, P=0.0001, respectively).Elevated serum Lp(a) levels are associated with the number of plaques and plaque morphology. Patients with a high Lp(a) level during AMI require more intensive treatment for plaque stabilization.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
ledong关注了科研通微信公众号
1秒前
U9A发布了新的文献求助10
1秒前
4秒前
任伟超发布了新的文献求助10
4秒前
U9A关闭了U9A文献求助
5秒前
牙牙完成签到,获得积分10
6秒前
6秒前
6秒前
8秒前
霸气乘风完成签到,获得积分10
9秒前
Jasper应助封从霜采纳,获得10
10秒前
小王发布了新的文献求助10
10秒前
小谢发布了新的文献求助20
11秒前
12秒前
Emma发布了新的文献求助10
13秒前
16秒前
zxt完成签到,获得积分10
17秒前
Thy发布了新的文献求助10
18秒前
19秒前
U9A发布了新的文献求助10
19秒前
一一发布了新的文献求助10
19秒前
19秒前
ledong发布了新的文献求助10
20秒前
20秒前
20秒前
21秒前
21秒前
23秒前
24秒前
U9A关闭了U9A文献求助
24秒前
JINCHANG完成签到,获得积分10
24秒前
Mayday发布了新的文献求助10
24秒前
26秒前
Kyle发布了新的文献求助30
26秒前
Allen发布了新的文献求助10
27秒前
LiRay发布了新的文献求助10
27秒前
Lily会发财发布了新的文献求助10
31秒前
26岁顶级保安完成签到,获得积分10
32秒前
无限猕猴桃完成签到,获得积分10
36秒前
36秒前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Social Research Methods (4th Edition) by Maggie Walter (2019) 1030
A new approach to the extrapolation of accelerated life test data 1000
Indomethacinのヒトにおける経皮吸収 400
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 370
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3993587
求助须知:如何正确求助?哪些是违规求助? 3534299
关于积分的说明 11265206
捐赠科研通 3274074
什么是DOI,文献DOI怎么找? 1806303
邀请新用户注册赠送积分活动 883118
科研通“疑难数据库(出版商)”最低求助积分说明 809712