鼻周皮质
神经科学
颞叶
记忆的神经解剖学
长期记忆
语义记忆
情景记忆
心理学
内嗅皮质
海马旁回
海马体
识别记忆
外显记忆
认知
癫痫
作者
Larry R. Squire,Craig E.L. Stark,Robert E. Clark
出处
期刊:Annual Review of Neuroscience
[Annual Reviews]
日期:2004-06-24
卷期号:27 (1): 279-306
被引量:2557
标识
DOI:10.1146/annurev.neuro.27.070203.144130
摘要
▪ Abstract The medial temporal lobe includes a system of anatomically related structures that are essential for declarative memory (conscious memory for facts and events). The system consists of the hippocampal region (CA fields, dentate gyrus, and subicular complex) and the adjacent perirhinal, entorhinal, and parahippocampal cortices. Here, we review findings from humans, monkeys, and rodents that illuminate the function of these structures. Our analysis draws on studies of human memory impairment and animal models of memory impairment, as well as neurophysiological and neuroimaging data, to show that this system (a) is principally concerned with memory, (b) operates with neocortex to establish and maintain long-term memory, and (c) ultimately, through a process of consolidation, becomes independent of long-term memory, though questions remain about the role of perirhinal and parahippocampal cortices in this process and about spatial memory in rodents. Data from neurophysiology, neuroimaging, and neuroanatomy point to a division of labor within the medial temporal lobe. However, the available data do not support simple dichotomies between the functions of the hippocampus and the adjacent medial temporal cortex, such as associative versus nonassociative memory, episodic versus semantic memory, and recollection versus familiarity.
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