Salivary Gland Tumors: Diagnostic Value of Gadolinium-enhanced Dynamic MR Imaging with Histopathologic Correlation

医学 磁共振成像 唾液腺 病理 间质细胞 微血管 核医学 动态增强MRI 放射科 免疫组织化学 材料科学 冶金
作者
Hidetake Yabuuchi,Tatsuro Fukuya,Tsuyoshi Tajima,Yoichi Hachitanda,Kichinobu Tomita,Mitsuru Koga
出处
期刊:Radiology [Radiological Society of North America]
卷期号:226 (2): 345-354 被引量:326
标识
DOI:10.1148/radiol.2262011486
摘要

To evaluate the diagnostic value of gadolinium-enhanced dynamic magnetic resonance (MR) imaging of salivary gland tumors and correlate the MR imaging and histopathologic findings.Thirty-three salivary gland tumors in 29 patients were examined preoperatively at gadolinium-enhanced dynamic MR imaging. There were 22 benign and 11 malignant tumors. Dynamic contrast material-enhanced MR images were obtained for 5 minutes. Time of peak enhancement (T(peak)) and washout ratio (WR) were determined from time-signal intensity curves (TICs). Microvessel count and cellularity-stromal grade were evaluated histopathologically. The strengths of correlations between T(peak) and microvessel count and between WR and cellularity-stromal grade were statistically analyzed. Statistical analysis was also performed to determine whether any differences among the various histopathologic tumor types existed [corrected]. In a validation study, 13 salivary gland tumors in 13 patients were examined consecutively.At a T(peak) of 120 seconds, malignant tumors could be differentiated from pleomorphic adenomas but not from Warthin tumors. A WR of 30%, however, enabled differentiation between malignant and Warthin tumors. Classification of TICs on the basis of a T(peak) of 120 seconds and a WR of 30% had high sensitivity (91%) and specificity (91%) in the differentiation of benign and malignant tumors. Correlations between T(peak) and microvessel count (P <.0001, rho = -0.800) and between WR and cellularity-stromal grade (P =.0105, rho = 0.572) were significant. The validation study also yielded high sensitivity (100%) and specificity (80%) in the differentiation between benign and malignant tumors.Gadolinium-enhanced dynamic MR imaging is useful for differentiating benign from malignant salivary gland tumors.
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