The Relation Between Non-Alcoholic Fatty Liver Disease and the Risk of Coronary Heart Disease in Koreans

医学 脂肪肝 血脂异常 内科学 混淆 代谢综合征 疾病 风险因素 肥胖 胃肠病学 弗雷明翰风险评分 肝病
作者
Suyeon Choi,Donghee Kim,Hwa Jung Kim,Jin Hwa Kang,Su Jin Chung,Min Jung Park,Young Sun Kim,Chung Hyun Kim,Seung Ho Choi,Won Kim,Yoon Jun Kim,Jung‐Hwan Yoon,Hyo‐Suk Lee,Sang‐Heon Cho,Myung‐Whun Sung,Byung‐Hee Oh
出处
期刊:The American Journal of Gastroenterology [Lippincott Williams & Wilkins]
卷期号:104 (8): 1953-1960 被引量:125
标识
DOI:10.1038/ajg.2009.238
摘要

OBJECTIVES: Non-alcoholic fatty liver disease (NAFLD) is known to be related to factors that predict the development of coronary heart disease (CHD), such as dyslipidemia, central obesity, and metabolic syndrome (MS). The aim of this study was to determine whether individuals with NAFLD have an elevated risk of CHD, as estimated using the Framingham risk score (FRS). METHODS: A total of 21,130 individuals who underwent a voluntary general health examination were recruited. NAFLD was diagnosed among these individuals on the basis of typical sonographic findings and a level of alcohol consumption of < 20 g/day. Of the 21,130 individuals, 3,780 were excluded because they had known causes of liver disease (1,690 were alcoholics, 975 had hepatitis B virus, 242 had hepatitis C virus, 91 had other hepatitis history, and 593 were taking medication known to produce fatty liver) or a history of heart disease (189). RESULTS: NAFLD was diagnosed in 5,769 of the 17,350 individuals (33.3%). The 11,581 normal individuals constituted the control group. The 5,769 individuals with NAFLD were split into two groups on the basis of ultrasonographic findings, that is, into a mild NAFLD group (n= 3,278) and a moderate-severe NAFLD group (n= 2,491). Individuals with NAFLD had an elevated risk of CHD, as estimated using FRS. Multivariable regression analysis, adjusted for confounding factors, showed a strong association between a higher FRS and NAFLD. CONCLUSIONS: Individuals with ultrasonographically detected NAFLD have an elevated 10-year risk of developing CHD as estimated using FRS. Furthermore, NAFLD was found to be independently related to the risk of developing CHD, regardless of classical risk factors and other components of MS.
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