睫状神经营养因子
轴突
再生(生物学)
坐骨神经
解剖
轴浆运输
生物
外周神经系统
外围设备
周围神经
神经营养因子
化学
神经科学
中枢神经系统
内科学
细胞生物学
医学
受体
作者
Zarife Sahenk,Jegatheesan Seharaseyon,Jerry R. Mendell
出处
期刊:Brain Research
[Elsevier]
日期:1994-08-01
卷期号:655 (1-2): 246-250
被引量:94
标识
DOI:10.1016/0006-8993(94)91621-7
摘要
The effect of ciliary neurotrophic factor (CNTF) on peripheral nerve regeneration was studied in 6-week-old rats following sciatic nerve transection and juxtaposition of proximal and distal stumps. Rats received intraperitoneal recombinant human CNTF, 1 mg/kg every other day for 12 days. In all CNTF-treated animals, the distribution of the anterograde transport of [3H]leucine-labeled material within the distal stump showed a distinct peak activity 21–24 mm distal to the nerve transection site. In contrast, the radioactivity in control nerves declined rapidly, distributed as a proximodistal gradient without a distinct peak. In addition, the amount of radioactivity returning from the growing axon tips in CNTF was significantly greater than controls. The correlative morphologic studies showed a well-advanced stage of myelination in regenerating axons in CNTF compared to controls. These combined in vivo correlative kinetic and morphological studies indicate that CNTF dramatically potentiates axonal regeneration by promoting a greater number of elongating axon tips into the distal stump.
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