计算生物学
肽
病毒学
医学
计算机科学
生物
生物化学
作者
Akira Yano,Atsuko Onozuka,Yasuko Asahi‐Ozaki,Shoichi Imai,Nobuhiro Hanada,Yoshikatsu Miwa,T NISIZAWA
出处
期刊:Vaccine
[Elsevier]
日期:2005-03-18
卷期号:23 (17-18): 2322-2326
被引量:67
标识
DOI:10.1016/j.vaccine.2005.01.031
摘要
For humoral immunization, it may be possible to make effective and safe peptide vaccines for various diseases by selection of proper B-cell epitopes. However, a lack of T-cell epitopes on short peptides, such as those associated with major histocompatibility complex (MHC)-restriction, is a major problem for peptide vaccine development. We propose a solution for the design of peptide vaccines that involves induction of broadly reactive T-cell epitopes via agretopes. The strategy involves positioning multi-agretope type peptides on the N-terminal side of a di-lysine linker and B-cell epitopes on the C-terminal side. The addition of the arginine-glysine-aspartate (RGD)-motif to the N terminus of the peptide enhances its immunogenicity, and enables nasal immunization without adjuvants.
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